双齿导向基团在钯催化sp~3杂化碳氢键官能团化反应中有着突出的活性.然而由于其与金属钯形成较强的螯合配位作用,二价钯中间体上只剩一个配位点供外加配体结合,给通过外加配体来调节反应中间体的活性和控制反应的立体选择性带来很大的困难.近日,南开大学元素有机化学国家重点实验室陈弓-何刚研究团队采用2-吡啶甲酸辅助基团(PA),手性联萘酚磷酸酯(BPA)配体实现了钯催化烷基胺底物苄位碳氢键的不对称芳基化反应,产物ee值 Bidentate targeting groups have outstanding activity in the palladium-catalyzed sp ~ 3 hybridization of hydrocarbon-hydrogen bonds. However, due to the strong chelate coordination with palladium, only one Coordination sites for the addition of ligand binding, to the ligand by adjusting the reaction intermediates and control the stereoselectivity of the reaction has brought great difficulties. Recently, the State Key Laboratory of Element Organic Chemistry Nankai University Chen Gong - He Gang The team used palladium-catalyzed paraldehyde (PA) and chiral binaphthol phosphate (BPA) ligands to catalyze the asymmetric arylation of palladium on the benzylic carbon bond of alkylamine substrates. The product ee value