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目的评价肾移植术前牙周基础治疗对环孢菌素A相关的牙龈增生的预防效果。方法选取即将行肾移植术且拟用环孢菌素A作为免疫抑制剂的患者20名,随机分为牙周干预组(A组)和对照组(B组),在平衡了年龄、性别等干扰因素的前提下,记录被研究者移植术前及术后3个月、6个月、12个月时的牙周指标。结果两组的牙周指标在肾移植术前比较差异无统计学意义(P>0.05);在观察期间,我们发现A组的PLI、SBI、PD指数在3、6、12个月与0个月比较有所下降,且差异有统计学意义(P<0.05),GHI指数随着时间推移均数有所升高,但各时间点之间差异并无统计学意义(P>0.05);B组的PLI、SBI、PD、GHI逐渐升高,且差异均有统计学意义(P<0.05)。结论牙周感染可能是肾移植术后环孢菌素A相关的牙龈增生的原因之一,术前进行牙周基础治疗对环孢菌素A相关的牙龈增生的发生有一定的预防作用。
Objective To evaluate the preventive effect of basic periodontal treatment of kidney transplantation on cyclosporin A-related gingival hyperplasia. Methods Twenty patients who underwent renal transplantation and who were taking cyclosporin A as immunosuppressive agents were randomly divided into periodontal intervention group (group A) and control group (group B), after balancing age, sex, etc. Interfere with the premise of under the premise of the researchers were recorded before transplantation and 3 months after surgery, 6 months, 12 months when the periodontal indicators. Results There was no significant difference in periodontal index between the two groups before kidney transplantation (P> 0.05). During the observation period, we found that the PLI, SBI and PD index of group A were significantly lower than that of group A at 3, 6 and 12 months (P <0.05). The GHI index increased with time, but there was no significant difference between each time point (P> 0.05); B Group PLI, SBI, PD, GHI gradually increased, and the differences were statistically significant (P <0.05). Conclusion Periodontal infection may be one of the causes of cyclosporin A-related gingival hyperplasia after kidney transplantation. Preoperative periodontal basic treatment may have a preventive effect on cyclosporin A-related gingival hyperplasia.