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目的 了解服用环孢素A(CsA)的器官移植患者牙龈增生的发生率和影响因素。方法 以 360例器官移植患者为对象 ,对其年龄、性别、用药时间、服用药物及口腔卫生等与牙龈增生的关系进行分析。结果 360例患者有 1 0 6例 (2 9.4 % )发生牙龈增生 ,同时服用钙离子通道阻滞剂类药物与牙龈增生密切相关 (P <0 .0 1 ) ,牙菌斑指数和龈沟出血指数与牙龈增生的发生率和严重程度密切相关 (P <0 .0 1 )。结论 同期服用环孢素A和钙离子通道阻滞剂类药物可能使牙龈增生的发生率和严重程度增加。
Objective To investigate the incidence and influencing factors of gingival hyperplasia in patients undergoing organ transplantation with cyclosporine A (CsA). Methods A total of 360 cases of organ transplant recipients were enrolled in this study. Their relationship with age, gender, medication duration, medication and oral hygiene and gingival hyperplasia was analyzed. Results One hundred and sixty-six cases (range: 9.4%) developed gingival hyperplasia. In addition, calcium channel blockers were closely related to gingival hyperplasia (P <0.01), and plaque index and sulcus bleeding The index is closely related to the incidence and severity of gingival hyperplasia (P <0.01). Conclusion Concurrent use of cyclosporin A and calcium channel blockers may increase the incidence and severity of gingival hyperplasia.