【摘 要】
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In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val- Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val- Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the ξ-amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species---hydroxyl radicals produced by the drug.
In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo [Val-Lys (DMQ-MA) -Gaba]. The cytotoxic agent conjugated to the N-terminal and the ξ-amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species --- hydroxyl radicals produced by the drug.
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