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金属硫蛋白(Metallothionein,简称MT)是一类低分子量(～6500D)、富含半胱氨酸(哺乳动物MT由61个氨基酸组成,其中20个为半胱氨酸)的金属结合蛋白.自从Margoshes首次从蓄积Cd的马肾中分离出该物质,已对其在Cd,Hg等重金属解毒中的重要性进行了大量的研究.最近的研究表明,除了肝、肾等实质性组织外,MT还广泛存在于血液、尿液和胆汁等细胞间液中.Nordberg最先通过色谱分离方法在载镉动物的血浆中监测到MT,后又被放射免疫法所证实,同时发现正常动物的血液中也含有MT.但是,关于血液MT的来源、
Metallothionein (MT) is a class of low molecular weight (~ 6500D) metal-binding proteins that are cysteine-rich (mammalian MT consists of 61 amino acids of which 20 are cysteines) For the first time, Margoshes isolated this substance from horse kidney that accumulates Cd, and has done a lot of research on its importance in the detoxification of heavy metals such as Cd and Hg.Recent research shows that in addition to the substantial tissues such as liver and kidney, MT It is also widely present in blood, urine, and bile fluids, and Nordberg first detected MT in the plasma of cadmium-bearing animals by chromatographic methods and was confirmed by radioimmunoassay. In the meantime, normal animal blood was found Also contains MT However, the source of blood MT,