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用激光多普勒血流仪对62例消化性溃疡患者胃粘膜血流量(GMBF)进行测定.结果表明,胃溃疡和十二指肠溃疡患者在活动期胃内各部位GMBF明显低于正常对照组(分别为P<0.01、P<0.05),其中胃溃疡患者的GMBF下降比十二指肠溃疡患者尤甚,而愈合期GMBF则明显增加;在活动期溃疡中央、边缘粘膜的GMBF明显低于周围粘膜(P<0.01),在愈合期则显著升高,超过周围粘膜.提示GMBF在消化性溃疡的发生、发展和愈合过程中起着重要的作用.
Gastric mucosal blood flow (GMBF) was measured in 62 patients with peptic ulcer by laser Doppler flowmeter.The results showed that GMBF in gastric ulcer and duodenal ulcer in patients with gastric ulcer was significantly lower than that in normal control (P <0.01, P <0.05, respectively). The decrease of GMBF in patients with gastric ulcer was more serious than those in patients with duodenal ulcer, while the GMBF in the healing phase was significantly increased. In the active central ulcer, the GMBF in marginal mucosa was significantly lower (P <0.01), and significantly increased at the healing phase, over the surrounding mucosa, suggesting that GMBF plays an important role in the pathogenesis, development and healing of peptic ulcer.