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目的 为探讨早期矽肺患者BAL液中表面活性物含量改变及其意义。方法 对矽肺 0 +期组 13人和Ⅰ期 5人 ,以及健康农民对照 7人 ,进行经纤支镜支气管肺泡灌洗收集BAL液 ,测定表面活性蛋白A(SP A)和磷脂 (PL)及其组分含量。结果 矽肺 0 +期组和Ⅰ期组SP A和磷脂及组分含量与对照组比较 ,差异无显著性意义 ,矽肺Ⅰ期组PG/PI低于对照组 ,矽肺 0 +期组SP A/PL高于对照组 ,差别有显著性意义 (P<0 0 5 )。结论 本研究表明 ,BAL从中SP A/PL升高 ,PG/PI降低是矽肺的早期效应指标
Objective To investigate the changes of surfactant in BAL fluid in patients with early silicosis and its significance. Methods BAL fluid was collected from bronchoalveolar lavage by bronchoalveolar lavage of 13 patients in silicosis stage 0 and 5 in stage Ⅰ, and 7 healthy peasant controls. The levels of surfactant protein A (SP A) and phospholipid (PL) and Its component content. Results Compared with the control group, the contents of SP A and phospholipid and the content of phospholipids and phospholipids in the 0 + group and the Ⅰ group were not significantly different. The PG / PI in the silicosis Ⅰ group was lower than that in the control group. The SP A / PL Higher than the control group, the difference was significant (P <0 05). CONCLUSIONS: This study shows that BAL is increased from SP A / PL and decreased PG / PI is an early indicator of silicosis