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患者，女，36岁。因多汗，多食，T_3、T_4增高，诊断为甲状腺功能亢进症（筒称甲亢症），服他巴唑（20mg/日）33天后，出现畏寒、发热、咽痛1天，WBC 1.3×10~9/L，其中N 0.04，于1984年6月26日入院。入院后，出现寒战高热，皮肤黄染、搔痒，口鼻、阴道出血，口腔粘膜及齿龈坏死，肛周感染，大汗，脉速（110～130/分），肝、脾轻度肿大。WBC减至0.2×10~9/L，N为0。咽拭子培养：绿脓杆菌生长。血培养：阴性。肝功能试验：ZnT、TTT正常，SGPT 143~u，血清胆红素102.6μmol/L，凡登白试验呈直接立即反应；尿胆红素阳性，尿胆原含量正常（结合病史，提示黄疸为肝内淤滞型）。骨髓象：骨髓增生略为低下，粒系统细胞几乎全部缺如，比率仅占3％，粒红比值为0.06:1。
Patient, female, 36 years old. Because of sweating, eating more, T_3, T_4 increased diagnosis of hyperthyroidism (tube called hyperthyroidism), taking methimazole (20mg / day) 33 days after onset of chills, fever, sore throat 1 day, WBC 1.3 × 10 ~ 9 / L, of which N 0.04, was admitted on June 26, 1984. After admission, chills, fever, yellow skin, itching, nose and mouth, vaginal bleeding, oral mucosa and gingival necrosis, perianal infection, sweating, pulse rate (110-130 / min), mild enlargement of liver and spleen. WBC reduced to 0.2 × 10 ~ 9 / L, N is 0. Throat swab culture: Pseudomonas aeruginosa growth. Blood culture: negative. Liver function tests: ZnT, TTT normal, SGPT 143 ~ u, serum bilirubin 102.6μmol / L, Vandenbai test was immediate and immediate response; urinary bilirubin positive, normal urinary gallstalk (combined with history, suggesting that jaundice Liver stasis type). Bone marrow: bone marrow hyperplasia slightly lower, granulosa cells almost all absent, the rate of only 3%, the ratio of grainy 0.06: 1.