原发进行性失语(PPA)系一临床综合征,1982年由Mesulam报道,至今已有60多例,但尚缺乏病理资料。作者报告1例临床诊断为Pick氏病的PPA患者的脑部病理特点。 患者男,59岁。因进行性流利性失语9年就诊。系列CT扫描显示双侧外侧裂增宽,左侧明显,MRI显示双侧颞叶严重萎缩,EEG正常。病程中患者出 Primary progressive aphasia (PPA) is a clinical syndrome, reported by Mesulam in 1982, so far there are more than 60 cases, but the lack of pathological data. The authors report a case of brain pathology in one patient with PPA clinically diagnosed as Pick’s disease. Male patient, 59 years old. Due to progressive fluent aphasia 9 years treatment. Serial CT scans showed bilateral lateral cleft broadened, the left obvious, MRI showed severe bilateral atrophy of the temporal lobe, EEG normal. Patients in the course of disease out