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  5. Tanshinol protects against hydrogen peroxide-induced oxidative stress via regulating Wnt/FoxO pathwa

Tanshinol protects against hydrogen peroxide-induced oxidative stress via regulating Wnt/FoxO pathwa

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：zangming
【摘 要】
：
Aim: The "Aging and Oxidative Stress" theory is recently thought as a new mechanism of the pathogenesis related to osteoporosis.In our previous study, Tanshinol isolated from Salvia miltiorrhiza Bge (
【作 者】
：
Ya-jun YANG Ya-hui CHEN Tie WU Liao CUI 
【机 构】
：
Department of Pharmacology,Guangdong Key Laboratory for Research and Development of Natural Drug,Gua
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
tanshinol oxidative stress osteoporosis Wnt FoxO hydrogen peroxide C2C12 cells 
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Aim: The "Aging and Oxidative Stress" theory is recently thought as a new mechanism of the pathogenesis related to osteoporosis.In our previous study, Tanshinol isolated from Salvia miltiorrhiza Bge (Danshen) showed effectively activities to prevent or reverse bone loss and up-regulate Wnt signaling in excess Glucocorticoid (GC) (a factor induced oxidative stress) induced osteoporosis or GC-treated rat marrow stromal cell (rMSC).
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