Aim: Cepharanthine hydrochloride, a bisbenzyl isoquinoline alkaloid, which is extracted from the roots of stephania cepharantha and then salificatied with hydrochloric acid.Our previous studies have showed that CH could inhibited the replication of Hepatitis B Virus (HBV).This thesis mainly aims to study the antiHBV mechanism of CH in HepG2.2.15 cells and its effects on expression levels of NF-κB, further explores their connection.