Hepatoprotetive effects of curcumin against alcohol-induced liver injury via activation of Nrf2/ARE

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户:BESTWANGLOVE
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: Curcumin, a natural polyphenol in the spice turmeric, exhibits a good antioxidant property.NF-E2-Related Factor-2 (Nrf2) is a transcription factor that plays a crucial role in the cellular protection against oxidative stress.The present study was to investigate the protective effects of curcumin on alcohol-induced hepatic injury and its underlying mechanism.
其他文献
Aim: Rhinovirus (RV)-induced asthma exacerbation has put a great burden on the healthcare management of asthmatics.The aim of this study was to investigate the effects of anti-malarial drug artesunate
Aim: This study investigated the effects of cucurbitacin E (CUE), a tetracyclic triterpenes compound from Traditional Chinese medicine, on the cytochrome P450 (CYYP) 1A2 (phenacetin-O-deethylase), 2C
Aim: Bu-zhong-yi-qi-tang (HET) is a traditional Chinese medicine used for the treatment of spleen-deficiency in clinic.However, the mechanism responsible for its actions has not been investigated expe
Aim: Impaired wound healing in diabetic patients is a serious complication with limited treatment regimens.Gene therapy of mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) was a
Aim: Negative affective state is thought to be an important factor that triggers relapse.In this study, the role of insular cortex (IC) on the conditioned place aversion (CPA) in mice was investigated
Aim: Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.In this study, we determined whether Salvi
Aim: Cepharanthine hydrochloride, a bisbenzyl isoquinoline alkaloid, which is extracted from the roots of stephania cepharantha and then salificatied with hydrochloric acid.Our previous studies have s
Aim: This study aims to test the effects and mechanisms of anti-migration, antiadhesion and anti-invasion of ganoderiol A-enriched extract (GAEE) isolated from Ganoderma lucidum, a famous traditional
Aim: Licorice (LE) was reported hepatoprotective under several models in vivo.Glycyrrhizin is the major bioactive component isolated from LE herb.In the present study the effect of glycyrrhizin on the
Aim: In-vitro cultured Calculus bovis (ICCB) is an artificial substitute of natural Calculus bovis, which has been widely used for sedation, relieving fever and hepatic disease since ancient times.The