【摘 要】
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While chromatin modifications can offer a useful readout for enhancer activities, it is still unclear if these modification marks are a cause or consequence of transcription factor occupancy and enhan
【机 构】
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Faculty of Medicine University of Ottawa Canada
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While chromatin modifications can offer a useful readout for enhancer activities, it is still unclear if these modification marks are a cause or consequence of transcription factor occupancy and enhancer activation.Recently, my research team has studied the temporal events of acetyltransferase association and histone modifications at different regulatory regions of myogenic locus.Our studies revealed that histone acetyltransferase (HAT) p300 is stepwise enriched at distinct myogenic regulatory regions during stem cell differentiation.
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