【摘 要】
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Objective Cholangiocarcinoma(CCA),which arises in the bile duct,is the second most common primary hepatobiliary malignancy.Although CCA is usually considered as highly malignant with poor prognosis,su
【机 构】
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Fudan University Shanghai Cancer Center
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Objective Cholangiocarcinoma(CCA),which arises in the bile duct,is the second most common primary hepatobiliary malignancy.Although CCA is usually considered as highly malignant with poor prognosis,survival has been improved due to advances in early diagnosis and therapeutic approaches in the past few years.As the number of cancer survivors increases,it is important to evaluate the risk of second primary malignancy(SPM)in CCA survivors,which can provide insight into post treatment surveillance of patients with CCA.Previous studies have shown significantly increased risk of SPM after treatment of primary cancer in various solid tumors,including hepatocellular carcinoma,the most frequent primary hepatic malignancy.However,evaluation of the risk of developing SPM in patients with CCA is still lacking.Our study aims to investigate the overall and site-specific risk of SPM in patients with CCA and further evaluate the impact of SPM on overall survival(OS)and disease specific survival(DSS)of patients with CCA.
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