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Objective: To determine the clinical characteristics and prognostic factors of patients with secondary malignant neoplasm (SMN) following non-Hodgkins lymphoma (NHL).Methods: Clinical data of patients with SMN after treatment for NHL from year 2001 to 2010 in our department were collected and analyzed.Results: A total of 54 SMN cases were found (35 males and19 females).Multivariate Cox regression analyses showed that Ann Arbor stage of NHL is not only an independent prognostic factor of SMN, but also has significant independent impacts on the secondary tumor-free duration.Conclusion: The recognition of SMN must be improved.Ann Arbor stage of NHL may improve the remote outcome.