gluconeogenesis相关论文
SL010110,a lead compound,inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and imp
Suppression of excessive hepatic gluconeogenesis is an effective strategy for controlling hyperglycemia in type 2 diabet......
Negative energy balance (NEB),which is characterized by low serum glucose and hyperketonemia,is the pathology basis of k......
Hypoglycemic effect of co-administration of berberine and sodium caprate via AMPK in inhibiting hepa
Aim: Berberine (BER), a natural product and active ingredient of genera Berberis and Coptis, has been demonstrated to po......
Role of FADD phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiolo
Fas-associated death domain-containing protein (FADD),a classical apoptotic signaling adaptor,also takes part in many no......
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced
The effect and potential molecular mechanisms of berberine on gluconeogenesis in skeletal muscles and adipose tissues we......
Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes
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Renal gluconeogenesis is one of the major pathways for endogenous glucose production.Impairment in this process may cont......
Autophagy, including macroautophagy, microautophagy, and chaperone-mediated autophagy,plays critical roles in recycl......
Effects of flavonoids-rich Chinese bayberry(Morella rubra Sieb.et Zucc.)fruits extract on regulating
In the present study,male diabetic KK-Ay mice were used to investigate the antidiabetic effect of bayberry fruits ex......
Chromium-containing traditional Chinese medicine, Tianmai Xiaoke Tablet improves blood glucose throu
OBJECTIVE: Chromium is an essential mineral that is thought to be necessary for normal glucose homeostasis. Numerous stu......
目的:研究Irisin对2型糖尿病(type 2 diabetes mellitus,T2DM)小鼠血糖的影响及机制.方法:采用喂养高脂饮食结合腹腔注射小剂量的......
,Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-
AIM: To compare the acute effects of l-caitine (LCT) and dl-camitine (DLC) on hepatic catabolism of l-alanine andl-gluta......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
目的研究丙型肝炎病毒(HCV)非结构蛋白5A（NS5A）及其片段NS5A结构域I、结构域Ⅱ、结构域III调节小鼠糖异生的机制。方法60只C57BL/6J......
目的观察羟甲基戊二酰辅酶A还原酶降解蛋白1(HRD1)在肝脏糖异生中的作用。方法采用Western blot法检测5只饥饿小鼠、4只高脂饮食小......
Glucose Metabolic and Gluconeogenic Pathways Disturbance in the Intrauterine Growth Restricted Adult
Objective To explore the molecular mechanism of type 2 diabetes in intrauterine growth restricted adult rats through det......
Glucose Metabolic and Gluconeogenic Pathways Disturbance in the Intrauterine Growth Restricted Adult
Objective To explore the molecular mechanism of type 2 diabetes in intrauterine growth restricted adult rats through det......
目的 探讨核糖体蛋白S6激酶1基因沉默对db/db小鼠肝脏胰岛素抵抗的影响及机制.方法 采用随机数字表法将24只9周龄健康雄性db/db小......
目的 探讨Exenatide对肥胖大鼠肝脏糖异生基因表达的作用. 方法 将雄性SD大鼠随机分为高脂饮食(HF)组、高脂用药(HF+ Exe)组与正常......
Kruppel样因子15(KLF15)是Kruppel样转录因子家族中的一员.Kruppel样转录因子家族特征性结构是含有3个Kruppel样锌指结构,与DNA的C......
果糖1,6-二磷酸酯酶(FBPase)是糖异生途径中的关键酶,广泛分布于植物、动物及微生物中,研究其功能调控的分子机制具有重要的生物学......
目的:探讨微小核糖核酸106b(miR-106b)对肝细胞葡萄糖异生作用及其机制。方法:正常人L02肝细胞培养于含10%胎牛血清的DMEM中,利用m......
本项试验使用了＾１４Ｃ标记的丙酸和葡萄糖；用同位素示踪技术研究了全营养灌注绵羊改变瘤胃灌注混合挥发性脂肪酸中乙／丙酸比例后，丙酸糖异生......
葡萄糖是脑细胞等中枢神经系统和胚胎的主要供能物质,也是泌乳奶牛合成乳糖的前体物质,并且与乳脂、乳蛋白合成密切相关,对泌乳奶......
蒺藜水煎剂能够明显抑制正常小鼠的糖异生作用,影响糖代谢;同时能够明显抑制糖异生小鼠血清甘油三酯水平,降低幅度为27.82%;对血清......
目的:评价青钱柳中5种三萜酸成分,即化合物1(arjunolic acid)、化合物2(hederagenin)、化合物3(3β,23-dihydroxy-12-ene-28-ursol......
目的：探讨p62^dok表达与肝细胞葡萄糖异生间的相互关系.方法：利用小鼠高脂饮食模型,观察p62^dok表达与肝组织胰岛素信号转导和葡萄糖......
[目的]研究饥饿大鼠皮肤暴露一氯乙酸（Monochloroacetic，MCA）在临床症状出现之前的急性毒性。[方法]皮下注射MCA（LD50：162mg／ml体重）2h后......
目的：探讨补充支链氨基酸（BCAA）对不同负荷运动后及恢复期糖代谢和糖异生的影响。方法；20名赛艇运动员随机分为2组（BCAA组和对照组），BCAA......
目的探讨禁食条件下急性细菌脂多糖（LPS）暴露对小鼠血糖的影响。方法雄性成年ICR健康小鼠随机分为对照组和LPS组，LPS组单次腹腔注射2m......
为了解兔胆原性脓毒症后不同时相肝细胞糖异生功能及其对有关糖异生激素的反应性，探讨肝细胞代谢功能改变与血糖水平之间的关系。于......
罗汉果皂苷Ⅱ是罗汉果嫩果的主要皂苷成分,味道极苦,在罗汉果生产季节的末期大量滞长果（苦果）因为天气原因而产生,这些滞长果因体内......
Effects of Dietary Citric Acid on Metabolic Indicators and Gene Expression in the Skeletal Muscles o
Citric acid is recognized and utilized as a dietary supplement for its ability to eliminate fatigue. However, the molecu......
The action mechanism of ranolazine, an antiangina drug, could be at least partly metabolic, including inhibition of fatt......
Fatigue Alleviation Mechanism of Citric Acid Determined by Gene Expression Analysis in the Mouse Liv
Citric acid has been recognized for its ability to alleviate fatigue;however, the mechanism contributing to this effect ......
Intraperitoneal administration of the non-selective adenosine receptor agonist 5’-N-ethylcarboxamide-adenosine (NECA) (......
Perceptions and Use of Herbal Remedies among Patients with Diabetes Mellitus in Murang’a North Distr
Diabetes mellitus is a chronic disease with a world wide distribution. Use of herbal remedies has been on increase with ......
Effect of Iron-Mediated Oxidative Stress on Insulin Resistance Through the Forkhead Box-Containing P
Aims: Chronic hepatitis C virus (HCV) infection is often associated with glucose metabolic disorders and iron overload. ......
The effects of the supplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GDP)on the progression of the systemic a......
Responses of the perfused liver of neonatal type 2 diabetic rats to gluconeogenic and ammoniogenic s
The responses of livers from rats with type 2 diabetes to alanine (gluconeogenesis and ammonia detoxification) and other......
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced
The effect and potential molecular mechanisms of berberine on gluconeogenesis in skeletal muscles and adipose tissues we......
Using mice that lack retinaldehyde dehydrogenase 1 gene(Raldh1-/-mice),Kierfer et al demonstrated that retinoids(metabol......
Background:Dexamethasone(Dex),a synthetic glucocorticoid,is among the most commonly used drugs worldwide in animals and ......
