LEUKEMIA相关论文
目的:探讨伴第21号染色体内部扩增（iAMP21）的儿童急性B淋巴细胞白血病（B-ALL）的临床特征及预后。方法:回顾性分析2019年1月至2020年12......
慢性粒细胞白血病（CML）靶向药物-酪氨酸激酶抑制剂（TKI）的应用极大改善了CML患者的预后。但TKI不间断的治疗影响患者的生命质量、加重......
靶向药物为急性髓系白血病（AML）治疗带来巨大进步。随着研究的深入，靶向药物治疗耐药、联合治疗不良反应叠加、缺乏有效靶点等问题亦......
PARP-1 inhibitors enhance the chemosensitivity of leukemia cells by attenuating NF-κB pathway activi
Idarubicin(IDA),an anthracycline antineoplastic drug,is commonly used in the treatment of acute myeloid leu-kemia(AML)wi......
PEGylated-L-asparaginase(PEG-ASNase)is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia(ALL......
目的:了解湖南省慢性淋巴细胞白血病(CLL)分布规律及流行病学特征。方法:按照国家肿瘤登记中心指定的审核方法和评价标准，共纳入24......
目的:探究维奈克拉联合阿扎胞苷（Ven+AZA）在初治不适合强化疗（unfit）及难治（≥1次强化诱导化疗未缓解）/复发（R/R）急性髓系白血病（AML）患者中......
目的:探索开发一种靶向CLL-1的嵌合抗原受体T细胞（CAR-T细胞）并验证其功能。方法:通过流式细胞术检测急性髓系白血病（AML）细胞系和AML......
目的 回顾性分析骨髓移植治疗白血病优质护理的应用效果.方法 选取本院2016年01月-2020年01月收治的58例骨髓移植治疗白血病患者开......
目的:分析初诊急性淋巴细胞白血病（ALL）患者融合基因的表达情况，进一步探讨融合基因阳性患者的实验室检查特点。方法:回顾性分析2016......
目的:探讨基于生态系统理论（EST）为指导的家庭管理联合互动式健康教育在白血病患儿护理中的应用效果。方法:采用便利抽样法，于2019年2......
在酪氨酸激酶抑制剂（TKI）治疗时代，慢性粒细胞白血病（CML）已具有“慢病化管理”的趋势。虽然四代TKI药物相继出现，但是CML的治疗需求仍有......
总结纵隔生殖细胞肿瘤(GCTs)并发恶性血液病(HM)患儿的临床特征及治疗预后。回顾性收集2014年11月至2018年9月北京儿童医院肿瘤内......
分析郑州大学附属肿瘤医院采用Bcl-2抑制剂维奈托克联合酪氨酸激酶抑制剂（TKI）及含地塞米松小剂量化疗方案治疗5例复发/难治（R/R）费城......
目的:探讨长链非编码RNA（lncRNA）C9ORF139靶向微小RNA（miR）-24-3P/TAOK1调控急性髓系白血病（AML）细胞增殖的作用和机制。方法:AML细胞株（......
Lentiviral vectors (LVs),derived from human immunodeficiency virus,are powerful tools for modifying the genes of eukaryo......
目的:探究利奈唑胺治疗老年白血病患者化疗后伴革兰阳性（Gn +）球菌感染的临床疗效及不良反应。n 方法:选取义乌市中心医院2......
目的:探讨初诊急性髓系白血病（AML）患者的基因突变分布特点及其与预后的关系。方法:回顾性分析2016年5月至2019年12月就诊于空军军医......
目的:探讨低剂量地西他滨联合DA/HA化疗方案对预后中等及不良急性髓系白血病（AML）患者的疗效与安全性。方法:回顾性分析西南医科大学......
目的:探讨我国东北地区伊马替尼耐药的慢性粒细胞白血病（CML）和费城染色体阳性急性淋巴细胞白血病（Phn + ALL）患者BCR-ABL1激酶区......
目的:提高对伴t（14；18）（q32；q21）慢性淋巴细胞白血病（CLL）的认识。方法:回顾性分析天津金域医学检验实验室2020年1月至2021年1月3例伴t（14；18......
异基因造血干细胞移植（allo-HSCT）是治愈急性淋巴细胞白血病（ALL）的有效手段之一。文章基于第63届美国血液学会（ASH）年会相关内容，讨论靶......
肾母细胞瘤(n WT)n 1基因位于人类染色体11p13，其编码的WT1具有抑制肿瘤生长与激活癌基因转录的双重功能，是一个双向转录因......
Arsenic Disulfide Induced Apoptosis and Concurrently Promoted Erythroid Differentiation in Cytokine-
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Research on inhibitory effects of synthetic peptideas LFA-1 antagonist on leukemia cells adhesion to
LFA-1 (Lymphocyte function-associated antigen 1, also known as CD1 la/CD18) belongs to the β2 intergrin family and is e......
Most of leukemia cells highly express CXCR4,a seven-transmembrane G-protein-coupled chemokine receptor (GPCR).In bone ma......
A small synthetic CXCR4 antagonist peptide that blocks adhesion of leukemia cells to stromal microen
Adhesion of leukemia cells to stromal cells confers resistance tospontaneous and drug-induced cell death of leukemia cel......
Inhibitory role of selective synthetic polypeptide against CXCR4 in migration of leukemia cells to s
Many leukemia cells highly express chemokine receptor of CXCR4 that actively responses to CXCL12 constitutively secreted......
Objective To evaluate the CT features of fungal infection in children with leukemia.Methods This is a retrospective anal......
目的 Pulmonary alveolar proteinosis(PAP) is a rare pulmonary disease. There are three clinically distinct forms of PAP： c......
...
The switch from WT1 to Egr-1 binding on TGF-β1 promoter contributes to the committed differentiation
Aims: Early growth response gene l(Egr-1) and The Wilmstumor 1 (WT1) have been implicated in macrophage differentiation ......
Angiogenesis, new blood vessel formation, is fundamental to tumor progression and spread, which has been documented for ......
A novel PADI4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute prom
Aims: The hematologic malignancy acute promyelocytic leukemia (APL) exhibits a failure of myeloid differentiation.Most p......
Both the down-regulation of c-myc and activation of apoptosis pathway are involved in anti-prolifera
Aim: Baicalin has been documented to induce apoptosis of leukemia-derived T cell line,Jurkat cells,via mitochondrial pat......
Development of new Jurkat cell lines insensitive to epirubicin and biological properties of them are
There are few methods to evaluate the state whether cancer cells are cleared up after chemotherapy, and the connection b......
Objective:It is first report that one lung cancer secondary to leukemia with Bone Marrow Transplantation was treated by ......
ClinicalAnalysisandPrognostic Significance of Malignancy-associated Haemophagocytic Lymphohistiocyto
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Generation and preclinical characterization of an NKp80-Ig fusion protein for redirection of NK cell
Backgroud: The capability of NK cells to mediate Fc-receptor dependent effector functions like ADCC largely contributes ......
Objectives:Skeletalabnormalitiesareinvolvedinmostofthechildrenwithacutelymphoblasticleukemia(ALL).Thisstudywasto investi......
PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, selec
LF11-322 (PFWRIRIRR-NH2) (PFR peptide), a nine amino acid-residue peptide fragment derived from human lactoferricin, pos......
IRF8 is a transcription factor with a critical role in B lymphocyte development and biological functions.In our previous......
Objective: To investigate the leukemia incidence among residents in the vicinity area of a nuclear installation.Methods:......
Arsenic Trioxide Prolongs Radiation-induced G2/M Arrest and Enhances its Apoptotic Effects in U937 C
The present study aimed at investigating the enhanced effects and genes expression in the cell cycle distribution and ap......
THE VALUE OF (1-3)-β-D-GLUCAN AND GALACTOMANNAN ANTIGEN FOR DIAGNOSIS INVASIVE ASPERGILLOSlS IN HEMA
to evaluate the early diagnostic value of (1-3)-β-D-glucan (BG),and galactomannan (GM) in hematological patients.Method......
Hematopoietic stem cells and progenitor cells (HSPC) are exhibit high radiosensitivity and their proliferation ability d......
Molecular mechanism of G1 arrest and cellular senescence induced by LEEO11, a novel CDK4/CDK6 inhibi
Background: Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature of many human cancers inc......
TET2 is a noveltumor suppressor gene involved in several hematological malignancies of myeloid and lymphoid origin.Besid......
T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce
Background: T-type Ca2+ channels are often aberrantly expressed in different human cancers and participate in the regula......
Objective: Our aim is to detect the expression profile ofNK ligands in acute leukemia cell lines and investigate the dif......
