Inhibitory role of selective synthetic polypeptide against CXCR4 in migration of leukemia cells to s

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：wxbft

【摘要】

：

【作者】

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Xiaojin Li Hua Guo Yanlian yang Jie Meng Jian Liu Chen Wang Haiyan Xu

【机构】

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Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical Colle

【出处】

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International Conference on Nanoscience & Technology,China 2

【发表日期】

：

2013年3期

【关键词】

：

CXCR4 CXCL12 antagonist leukemia stromal microenvironment migration

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　　Many leukemia cells highly express chemokine receptor of CXCR4 that actively responses to CXCL12 constitutively secreted by stromal cells or endothelial cells in the bone marrow and many organs.Activation of CXCR4 induces leukemia cells trafficking and homing to the marrow microenvironment or metastasis to target organs, where CXCL12 retains leukemia cells in close contact with stromal cells and endothelial cells that provide protection from chemotherapy In this study, we report one novel CXCR4 antagonist peptide (P3) screened from 20 small synthesized peptides targeting to human CXCR4.

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Inhibitory role of selective synthetic polypeptide against CXCR4 in migration of leukemia cells to s

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