A small synthetic CXCR4 antagonist peptide that blocks adhesion of leukemia cells to stromal microen

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：userbyf

【摘要】

：

【作者】

：

Xiaojin Li Hua Guo Yanlian Yang Jian Liu Jie Meng Chen Wang Haiyan Xu

【机构】

：

Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical Colle

【出处】

：

International Conference on Nanoscience & Technology,China 2

【发表日期】

：

2013年3期

【关键词】

：

CXCR4 CXCL12 antagonist leukemia stromal microenvironment adhesion

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　　Adhesion of leukemia cells to stromal cells confers resistance tospontaneous and drug-induced cell death of leukemia cells, and therefore is also termed cell adhesion-mediated drug resistance.The interaction between the chemokine receptor of CXCR4, which is highly expressed by many leukemia cells, and its ligand CXCL12, secreted bystromal cells within the marrow microenvironment, significantly promotes this adhesion.

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A small synthetic CXCR4 antagonist peptide that blocks adhesion of leukemia cells to stromal microen

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