GPCR相关论文
肥胖症（Obesity）又名肥胖病,是一种以身体脂肪含量过多为重要特征的生活方式疾病。肥胖是多种疾病发生的重要危险因素之一,如2型糖尿......
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G蛋白偶联受体（G protein-coupled receptor, GPCR）是药物研发中最受关注的靶点。目前，临床上市药物中约34%是以GPCR为作用靶点。但是......
降钙素受体（calcitonin receptor,CTR）是属于S类（Secretin,分泌素类）G蛋白偶联受体（G protein coupled receptor,GPCR）家族中的一员,广泛......
甲状腺癌是迄今为止发生频率最高的内分泌肿瘤,其发生率正处于逐年上升阶段。当下,手术切除仍是针对于甲状腺癌的主要治疗方式,其......
神经肽作为多样化、普遍存在的信号分子,具有多项重要生理调节作用。它们中的大多数通过与跨膜的G蛋白偶联受体（G-protein coupled ......
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G蛋白偶联受体(GPCRs)是生物体内重要膜受体,通过激活三聚体G蛋白参与各种细胞外信号转导,已在药物发掘中发挥着重要的作用.本文以......
The entomopathogenic fungus Metarhizium robertsii is widely used for biological control of a variety of insect pests.The......
目的 研究胆汁酸膜受体TGR5对非小细胞肺癌(NSCLC)迁移、活化的影响,探讨其分子机制.方法 检测13种NSCLC中TGR5的表达情况；选取TGR5......
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GRK2 is a member of the G protein-coupled receptor kinase (GRK) family,which serine/threonine phosphorylates and desensi......
Migrating cells display signal transduction events such as activation of PI3K and Scar/Wave and respond more readily to ......
G蛋白偶联受体(GPCR)是临床处方药物最重要的靶点,超过30％的临床处方药是直接作用在GPCR上的,相关的研究已经获得了10次诺贝尔奖.GP......
目的 内源性阿片肽及阿片受体系统,广泛分布于中枢神经系统内,具有强大的镇痛作用,并在奖赏、动机等行为调节方面发挥重要作用,同......
Hyperammonemia is frequently seen in liver diseases where it can lead to severe brain damage or death,as well as in tumo......
Unraveling a molecular determinant for clathrin-independent internalization and subsequent degradati
Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is of obvious importance for regulation of ......
目的 建立活细胞标记G 蛋白偶联受体(GPCR)的方法,采用荧光寿命成像(FLIM)结合荧光共振能量转移(FRET)分析GPR17(一种P2Y/CysLT 受......
In pancreatic beta cells, insulin secretion is trigged by calcium and greatly amplified by cAMP/protein kinase A (PKA), ......
G protein-coupled receptors(GPCRs)represent the largest class of cell surface proteins and thus constitute an important ......
Accelerating the throughput of affinity mass spectrometry-based ligand screening towards G-protein c
As an important transmembrane signaling modulator,G protein-coupled receptors(GPCRs)account for more than 30%of the mark......
Glucagon-like peptide-1 receptor(GLP-1R),as a member of the class B G protein-coupled receptors(GPCRs),plays a crucial r......
G protein-coupled receptors(GPCRs),a superfamily of integral transmembrane proteins regulate a variety of physiological ......
昆虫速激肽(Tachykinin-related peptides,TRPs)是首次在飞蝗(Locusta migratoria)中发现并分离纯化出的一种对其后肠肌肉组织......
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Molecular dynamics simulations provide insight into the mechanism of the mutation-caused constitutiv
G-protein-coupled receptors(GPCRs)are versatile signal regulators and pivotal targets for wide spectrum of diseases ......
The human glucagon receptor(GCGR)belongs to the class B G protein-coupled receptor(GPCR)family and plays a key role ......
Dopamine is found in relatively high levels throughout the insect nervous system and is the most abundant monoamine ......
作为最大的受体家族,G蛋白偶联受体调控多种细胞信号转导通路,参与多种重要的生理及病理过程.目前,大约40％的药物均以GPCR为靶标进......
Obesity is a rapidly growing health threat in modern society with only limited progress towards effective interventi......
Methuselah（MTH）是果蝇来源的GPCR中的一员，它的突变可延长果蝇平均寿命并提高果蝇对外界胁迫因素的耐受性。但目前对MTH在细胞水平的......
BI-167107是一种新的长效β2肾上腺素受体(β2-AR)激动剂,在鉴定G蛋白偶联受体(GPCR)/配体络合物的结构方面具有重要应用.以2-硝基......
G蛋白偶联受体（G protein-coupled receptor,GPCR）作为最大的一类人膜蛋白受体家族和最重要的药物靶标而倍受关注,其中钙离子在细胞......
前列腺癌开始时属于雄激素依赖性,在接受药物或手术睾丸去势治疗后肿瘤退缩,但最终还是会转变为雄激素非依赖性而继续生长。现有......
Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, ......
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VLGR1(The very large G protein coupled receptor 1)是目前已知最大的 G 蛋白偶联受体(G protein coupled receptor,GPCR),其 mR......
短链脂肪酸通常由肠道微生物对食物纤维的发酵而产生,已有报道其在免疫和炎症中起重要作用。本文研究丁酸钠通过其受体GPR43对T淋......
星形胶质细胞在中枢神经系统中扮演重要角色。此外,作为分泌性细胞,星形胶质细胞还活跃地参与被膜囊泡介导的细胞间通讯。当囊泡膜......
中国科学院上海药物研究所徐华强研究员领衔国际上28个实验室组成的交叉团队经过联合攻关,利用世界上最强X射线激光,成功解析视紫......
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Arrestins are soluble relatively smell 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs......
