β-cell相关论文
What can we learn fromβ-cell failure biomarker application in diabetes in childhood?A systematic rev
BACKGROUND The prevalence of diabetes as a catastrophic disease in childhood is growing in the world.The search for nove......
Association ofβ-cell function and insulin resistance with pediatric type 2 diabetes among Chinese ch
BACKGROUND In addition to insulin resistance,impaired insulin secretion has recently been identified as a crucial factor......
2型糖尿病是环境和遗传因素共同作用引起的代谢紊乱，是以胰岛素分泌不足和作用障碍引起高血糖为特征的临床综合征。此前，大多数关联......
目的探讨毛蕊异黄酮对链脲佐菌素（STZ）诱导的氧化应激和β细胞凋亡的作用以及机制。方法大鼠胰岛细胞系RIN-m5F细胞分为对照组、STZ......
Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine ce......
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,Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-ce
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为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
胰腺衍生因子(pancreatic derived factor,PANDER)是2002年新发现的细胞因子,主要表达于胰腺β细胞和α细胞.在β细胞内,PANDER与......
2型糖尿病是一种异质性疾病,主要的遗传因素是β细胞功能受损.功能改变表现为一系列的组织学、病理牛理学变化.2型糖尿病患者胰岛......
目的 观察血管紧张素Ⅱ(AngⅡ)对RIN-m β细胞胰岛素分泌的影响,探讨AngⅡ损伤β细胞功能的机制.方法 RIN-m细胞以不同浓度AngⅡ(0......
目的 观测胰岛素转录调控因子PDX-1、NeuroD1及MafA对小鼠骨髓间充质干细胞(mMSC)分化为胰岛素分泌细胞的作用.方法 分离培养扩增m......
During embryonic development, pluripotent endoderm tissue in the developing foregut may adopt pancreatic fate or hepatic......
目的研究幼年期高脂饮食对糖代谢、胰岛素敏感性和胰岛β细胞结构的影响。方法 60只雄性幼年SD大鼠随机分为高脂组和对照组,分别采......
柯萨奇Ｂ４病毒（ＣＢ４Ｖ）感染被认为和胰岛素依赖糖尿病（ＩＤＤＭ）原发病有关。我们对体外培养的小鼠胰岛和胰岛细胞经ＣＢ４Ｖ感染后，检测其胰岛素分泌功能。结果显......
采用我国流行的柯萨奇B4病毒(CB4V)感染swiss小鼠,建立Ⅰ型糖尿病的动物模型,并观察干扰素对CB4V引起的Ⅰ型糖尿病的保护作用.结果......
谷氨酸和γ一氨基丁酸受体主要分布在中枢神经系统，在神经信号转导中发挥着重要作用。近年来在胰岛中也发现了这类受体，且胰岛中几乎......
1型糖尿病是由于胰岛β细胞选择性破坏,而引起机体内胰岛素分泌绝对缺乏的一种自身免疫性疾病.肠促胰岛素在2型糖尿病的临床治疗中......
目的探讨肿瘤坏死因子（TNF-α）在胰岛素抵抗中的介导作用,以及对胰岛β细胞分泌功能的影响作用。方法随机选取SHG患者80例,测定血中T......
斑马鱼的个体小、高产和体外受精等特点使其已经迅速成为研究脊椎动物器官发育和人类疾病的模式生物之一。我们建立了一个转基因斑......
目的比较诺和龙与格列吡嗪对2型糖尿病的临床疗效。方法将单纯饮食及运动治疗控制不满意的2型糖尿病患者118例,随机分为诺和龙组(6......
目的：观察不同浓度的葡萄糖对胰岛β细胞脂质含量以及脂肪酸转位酶（CD36）表达的影响。方法：分别以5、10、15、20、253、0 mmol/L葡萄糖......
Backgroud:Current understanding of injury and regeneration of isletβ‐cells in diabetes is mainly based on rodent studi......
慢性高血糖不但是糖尿病的一个表现，而且通过损害胰岛素分泌和作用使代谢控制进一步恶化，这一现象被称为“葡萄糖毒性”。关于葡萄糖......
Objective: In this study, we assessed the level of fasting C-peptide as a predictor of β-cell function and insulin resi......
β-cell dysfunction and decreased insulin sensitivity are believed to be two chief mechanisms that participate in deteri......
Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylate......
Type 2 diabetes （T2DM） is characterized by insulinresistance and β-cell dysfunction. Although, in contrastto type 1 diabe......
Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined im
AIM To investigate the potential of implanting pseudoislets formed from human insulin-releasing β-cell lines as an alte......
Diabetes mellitus is increasing at an alarming rate andhas become a global challenge. Insulin resistance intarget tissue......
Melatonin is a circulating hormone that is mainly re- leased from the pineal gland. It is best known as a regulator of s......
Nutritional insufficiency during pregnancy has been shown to alter the metabolism of the offspring and can increase the ......
