论文部分内容阅读
用电镜方法观察了超剂量ＲＵ４８６对大鼠输卵管细胞超微结构所致的病理改变。实验大鼠给药７ｄ、１４ｄ、２８ｄ，每天３０ｍｇ／只。结果：实验组大鼠输卵管上皮细胞呈矮立方形，微绒毛减少，纤毛细胞消失，分泌细胞粗面内质网、高尔基复合体发育不良，核糖体减少；固有层中或纤维细胞胞质内出现胶原原纤维束及残余体样结构，间质中胶原纤维增多；固有层、外膜内可见较多嗜酸性粒细胞。表明超剂量ＲＵ４８６对输卵管粘膜细胞超微结构有一定损害。
Electron microscopy was used to observe the ultrastructural changes of tubal cells induced by RU486 in rats. Experimental rats administered 7d, 14d, 28d, 30mg / day. Results: The tubal epithelial cells in experimental group showed short cuboid, reduced microvilli, disappeared ciliated cells, secreted cell rough endoplasmic reticulum, dysplasia of Golgi complex, and decreased ribosomes. In the lamina propria or in the cytoplasm of fibroblasts, Collagen fibril bundles and residual body-like structure, interstitial collagen fibers increased; lamina propria, the outer membrane can be seen more eosinophils. The results showed that overdose RU486 had some damage to the ultrastructure of the oviduct mucosal cells.