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用电镜方法观察超剂量ＲＵ４８６对大鼠甲状腺两种细胞超微结构的影响。实验大鼠给药７ｄ、１４ｄ、２８ｄ，每天３０ｍｇ／ｍｌ／只。结果：各组大鼠甲状腺滤泡上皮细胞、滤泡旁细胞超微结构无显著病理改变。提示ＲＵ４８６对垂体一甲状腺轴影响不明显。
The effect of overdose RU486 on the ultrastructure of thyrocytes in rats was observed by electron microscopy. Experimental rats administered 7d, 14d, 28d, day 30mg / ml / only. Results: There was no significant pathological changes in the ultrastructure of thyroid follicular epithelial cells and parafollicular cells in each group. Tip RU486 on the pituitary-thyroid axis is not obvious.