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三组实验组大鼠分别给药７ｄ、１４ｄ、２８ｄ，每天３０ｍｇ／ｍｌ／只，光、电镜下观察超剂量ＲＵ４８６对大鼠皮质中的卵泡、间质腺以及基质中细胞的超微结构的影响。结果：多数卵泡闭锁，部分形成间质腺，腺细胞内含大量脂滴、空泡及次级溶酶体；基质中成纤维细胞、巨噬细胞增多，可见变异颗粒细胞、巨噬细胞胞质中出现巨大溶酶体及残余体样结构，其超微病理改变随用药时间延长加重。提示超剂量ＲＵ４８６对卵泡发育有抑制作用，并对卵巢皮质细胞有一定损害。
Three groups of experimental rats were administered 7d, 14d, 28d, 30mg / ml / day respectively. Under light and electron microscope, the effect of RU486 on the ultrastructure of follicles, interstitial glands and matrix in rat cortex influences. Results: Most of the follicles were atresia and formed part of the interstitial glands. The glandular cells contained a large number of lipid droplets, vacuoles and secondary lysosomes. The number of fibroblasts and macrophages in the matrix increased, showing that in the cytoplasm of the variant granulocytes and macrophages A huge lysosomal and residual body-like structure appeared, and its ultrastructural pathological changes were aggravated with the prolongation of drug use time. Tip over dose RU486 inhibit follicular development, and ovarian cortical cells have some damage.