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用电镜方法观察了超剂量ＲＵ４８６对大鼠肾上腺和甲状腺细胞超微结构的影响。实验大鼠给药７ｄ、１４ｄ、２８ｄ，每天３０ｍｇ／ｍｌ／只。结果：肾上腺皮质束状带细胞溶酶体增多增大，胞质内和细胞间出现髓样小体，巨噬细胞胞质中形成巨大残余样结构，其超微结构改变随用药时间延长加重。球状带、网状带、髓质细胞以及甲状腺滤泡上皮细胞、滤泡旁细胞超微结构与对照组无显著差别。提示超剂量ＲＵ４８６对大鼠肾上腺皮质束状带细胞有一定损害，但对肾上腺其它部位及甲状腺影响不明显。
The ultrastructure of adrenal and thyroid cells was observed by electron microscopy. Experimental rats administered 7d, 14d, 28d, day 30mg / ml / only. Results: The amount of lysosomes in adrenal cords increased, the myeloid bodies appeared in the cytoplasm and the cytoplasm, while the macrophage cytoplasm formed huge residual structures. The ultrastructural changes were aggravated with the prolongation of drug use time. Spherical zone, reticular zone, medulla cells and thyroid follicular epithelial cells, follicular paracellular ultrastructure and the control group no significant difference. Tip overdose RU486 rat adrenal cortical band cells have some damage, but the other parts of the adrenal glands and the thyroid is not obvious.