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目的 为了改善肽核酸的理化和生物学性质 ,对经典肽核酸的结构进行衍生化和修饰。方法 采用Ugi四组分缩合反应进行PNA单体的合成并采用Fmoc的保护策略。结果 合成了Fmoc保护的PNA单体和关键组分异腈。结论 建立了一种简单 ,灵活多变的合成PNA单体的方法。
Purpose To improve the physicochemical and biological properties of peptide nucleic acids, the structure of classical peptide nucleic acids is derivatized and modified. Methods Ugi four-component condensation reaction of PNA monomer synthesis and the protection strategy Fmoc. Results Fmoc-protected PNA monomer and key isonitrile were synthesized. Conclusion A simple and flexible method for synthesizing PNA monomer was established.