Diarylheptanoids, most of which appearing in the areas of anti-inflammatory, anti-oxidative, superoxide scavenging and anti-hepatotoxic effects, constitute a distinct group of metabolites of natural plants characterized by two aromatic rings linked by a linear seven aliphatic chain. We have investigated this kind of compounds and made some progress[1].1, 7-bis(4-hydroxy-phenyl)hepta-4E, 6E-dien-3-one 1were firstly isolated from the seeds of Alpinia blepharocalyx[2]. So far the synthesis of the compound has not been reported yet. Herein, we report the sysnthesis of compound 1 in Fig. 1, The synthetic route is outlined in Fig. 2.