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多形红斑病因不明。不少因素可诱发。最为人所知的,为在出疹前先发生单纯疱疹的感染。有报导在单纯疱疹发作后5～14天出现多形红斑。在多形红斑中可分离出单纯疱疹病毒。复发性单纯疱疹是临床上面临的一个常见又难治的问题。不少学者提出了多种疗法。DoRoeth(1963)用0.50％硫酸锌治疗疱疹性角膜炎成功。Merch Index(1968)推荐用0.2～1％硫酸锌局部治疗皮肤上单纯疱疹。但浓度太大会引起刺激、干燥和催吐反应。本文作者改用低浓度的办法来避免,并在临床上应用取得成功。
Erythema polymorphic etiology unknown. Many factors can be induced. The best known is herpes simplex infection before she rash. There are reports of polymorphic erythema occurring 5 to 14 days after the onset of herpes simplex. In polymorphic erythema herpes simplex virus can be isolated. Recurrent herpes simplex is a common and refractory problem in clinical practice. Many scholars have proposed a variety of therapies. DoRoeth (1963) successfully treated herpes keratitis with 0.50% zinc sulfate. Merch Index (1968) recommends topical treatment of herpes simplex skin with 0.2 to 1% zinc sulfate. However, too much concentration can cause irritation, dryness and emetic reactions. The authors use low-concentration approach to avoid, and in clinical application of success.