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本工作证实,pppA2′p5′A_2′p5′A(2′-5′P_3A_3)具有广泛的抗病毒作用,它能抑制RNA病毒如Influenza H_3N_2/77,Influenza H_1N_1/77,ECHO_(11),rhino,Sendal,Sindbis及VSV等病毒,也能抑制DNA病毒(如herpes Ⅰ型)在人胚皮肤肌肉成纤维母细胞中的致病,因而对病毒感染细胞起一定的保护作用。此外1μM2′-5′P_3A_3对个别病毒的作用效果(与其他病毒相比)甚至比512单位/毫升的干扰素(IFN)还好,这说明2′-5′P_3A_3在干扰素的抗病毒作用中具有很重要的意义。对2′-5′P_3A_3与IFN的抗病毒作用进行比较之后,发现对于多数病毒,二者虽有差异,但有一定的平行关系,少数病毒则二者差别甚远,所有这些差异可能是由于病毒本身的作用所引起。
This work confirmed that pppA2’p5’A_2’p5’A (2’-5’P_3A_3) has a wide range of antiviral activity and can inhibit RNA viruses such as Influenza H_3N_2 / 77, Influenza H_1N_1 / 77, ECHO_ (11), rhino , Sendal, Sindbis and VSV and other viruses, but also can inhibit the DNA virus (such as herpes type Ⅰ) in human embryonic skin fibroblasts pathogenic and thus play a protective role of virus-infected cells. In addition, the effect of 1 μM 2’-5’P_3A_3 on individual viruses (even compared with other viruses) was even better than that of 512 units / mL interferon (IFN), indicating that 2’-5’P_3A_3 has antiviral effects in interferon In the very important significance. After comparing the antiviral effect of 2’-5’P_3A_3 and IFN, we found that although there are some differences between the two viruses, there is a certain parallel relationship, while the few viruses are very different. All of these differences may be due to The virus itself caused by the role.