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Background: Since primary biliary cirrhosis (PBC) is usu- ally diagnosed in postmenopausal women with minor cholestasis, it has been que stioned whether PBC itself represents a further risk for osteoporosis. Aim: To a ssess the prevalence and risk factors for osteoporosis in an unselected series o f women with PBC. Patients and Methods: 142 women with PBC (age: 54.3±0.8 years ) and an age-matched control group. Osteoporosis was established by densitometr y (bone mineral density below -2.5 T-sc- ore). Age, duration and severity of PBC, body mass inde- x, menopausal status, histological stage and markers of bone turnover were ass essed. Results: Prevalence of osteoporosis was higher in PBC (32.4%) than in no rmal women (11. 1%)-(RR: 3.83, 95%CI: 2.59-5.67, P< 0.001). Osteoporosis was associated with older age, menopausal status, body mass index, longer PBC durat ion, advanced histological stage, high bilirubin and alkaline phosphatase, and l owalbumin and prothrombin index. Regression analysis identified older age, highe r Mayo risk score, lower body mass index and advanced histological stage but not menopause as the independent risk factors for osteoporosis. Conclusions: Osteop orosis is more prevalent in women with PBC than in the general population. Age a nd severity of the disease, but not menopausal status, are the main risk factors for osteoporosis in this liver disease.
Background: Since primary biliary cirrhosis (PBC) is usu-ally diagnosed in postmenopausal women with minor cholestasis, it has been queued or PBC itself represents a further risk for osteoporosis. Aim: To a ssess the prevalence and risk factors for osteoporosis in an Patients and Methods: 142 women with PBC (age: 54.3 ± 0.8 years) and an age-matched control group. Osteoporosis was established by densittr y (bone mineral density below -2.5 T-sc-ore) . Age, duration and severity of PBC, body mass inde- x, menopausal status, histological stage and markers of bone turnover were asssed. Results: Prevalence of osteoporosis was higher in PBC (32.4%) than in no rmal women (11. (RR: 3.83, 95% CI: 2.59-5.67, P <0.001). Osteoporosis was associated with older age, menopausal status, body mass index, longer PBC durat ion, advanced histological stage, high bilirubin and alkaline phosphatase , and owalbumin and prothrombin index. Regression a nalysis identified older age, highe r Mayo risk score, lower body mass index and advanced histological stage but not menopause as the independent risk factors for osteoporosis. Conclusions: Osteop orosis is more prevalent in women with PBC than in the general population. Age a nd severity of the disease, but not menopausal status, are the main risk factors for osteoporosis in this liver disease.