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研究脱落酸(ABA)对四氯化碳所致小鼠急性肝损伤的保护作用。70只ICR小鼠随机分为空白组、空白对照组、模型组、联苯双酯组、ABA高、中、低剂量组,连续ig给药10 d,于末次给药1 h后,除空白组和空白对照组按0.01 m L/g注射橄榄油外,其余各组均按体重注射体分数10%的CCl_4(CCl_4用橄榄油稀释),6 h后,脊椎脱臼处死小鼠,收集血液,检测血清中ALT、AST、TC、TG、HDL-c水平,取肝脏制备肝匀浆测定GSH-Px、MDA、SOD活性,HE染色,光镜下观察肝组织病理变化。结果表明:ABA各剂量组均能明显改善因CCl_4造成肝损伤引起的血脂异常,一定剂量的ABA可以降低肝损伤小鼠血清中ALT、AST水平的升高,降低肝匀浆中小鼠MDA含量,升高SOD、GSH-Px活性,减轻CCl_4对肝组织的病理损伤。ABA对CCl_4致小鼠急性肝损伤具有一定的保护作用,其保护机制可能与改善小鼠因CCl_4致小鼠急性肝损伤引起的血脂异常,清除自由基,抑制脂质过氧化,减轻肝组织的损伤有关。
To study the protective effect of abscisic acid (ABA) on carbon tetrachloride-induced acute liver injury in mice. 70 ICR mice were randomly divided into blank group, blank control group, model group, bifendate group, ABA high, medium and low dose groups, continuous ig administration for 10 days, after the last administration of 1 h, The mice in each group were injected with olive oil at the dose of 0.01 m L / g and blank control group. All the other groups were injected with 10% body weight of CCl_4 (CCl_4 diluted with olive oil). After 6 h, The levels of ALT, AST, TC, TG and HDL-c in the serum were detected. The liver homogenate was used to measure the activity of GSH-Px, MDA and SOD. The pathological changes of liver were observed under light microscope. The results showed that all doses of ABA could obviously improve the dyslipidemia caused by CCl_4 induced hepatic injury. A dose of ABA could reduce the level of ALT and AST in serum of mice with liver injury and decrease the level of MDA in liver homogenate, Increase the activities of SOD and GSH-Px and alleviate the pathological damage of liver tissue by CCl_4. ABA can protect CCl 4 -induced acute liver injury in mice, and its protective mechanism may be related to the improvement of dyslipidemia induced by CCl 4 -induced acute liver injury in mice, scavenging of free radicals, inhibition of lipid peroxidation, alleviation of liver injury Damage related.