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目的 探讨无水酒精局部注射 (PEI)术治疗复发性肝癌对癌细胞血行播散的影响。方法 应用巢式RT PCR检测复发性肝癌患者PEI术前后周围静脉血液中肝癌细胞的变化。结果 2 9例复发性肝癌患者PEI术前有 14例 (4 8% )周围血液中肝癌细胞阳性者 ;PEI治疗 4次 (1个疗程 )后阳性者减至 2例 (7% )。结论 PEI治疗复发性肝癌可以有效地预防或阻止肝癌再复发及远处转移的发生
Objective To investigate the effect of water-free alcohol injection (PEI) on the hematogenous spread of cancer cells in patients with recurrent hepatocellular carcinoma. Methods The changes of hepatocellular carcinoma cells in peripheral venous blood of patients with recurrent hepatocellular carcinoma before and after PEI were detected by nested RT-PCR. Results Fourteen patients (48%) had positive hepatocellular carcinoma cells before PEI in 29 patients with recurrent liver cancer. The positive rate of PEI in 4 patients after one course of treatment was reduced to 2 (7%). Conclusion PEI treatment of recurrent hepatocellular carcinoma can effectively prevent or stop recurrence of liver cancer and distant metastasis