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目的 探讨急性中、重度一氧化碳 (CO)中毒患者血一氧化氮 (NO)含量及其与动脉氧分压 (PaO2 )、二氧化碳分压 (PaCO2 )的关系。方法 应用硝酸还原酶法检测了急性CO中度中毒 14例、重度中毒 2 1例患者的血NO含量 ,并与PaO2 、PaCO2 进行相关分析。结果 急性中、重度CO中毒组患者血NO含量分别为 (36 .6 +9.9)、(35 .7+10 .7) μmol/L ,均明显低于对照组 [(6 4 .9+14 .3)μmol/L],差异有显著性 (P <0 .0 1) ;而中度和重度中毒组间比较 ,差异无显著性 (P >0 .0 5 )。直线相关分析表明 ,急性中、重度CO中毒患者血NO含量均与PaO2 呈明显正相关 ,r值分别为 0 .92 8、0 .891,均P <0 .0 1;与PaCO2 无明显相关性。结论 急性中、重度CO中毒患者的缺氧可能是导致血NO含量减少的重要原因 ,为吸入低浓度NO治疗急性CO中毒提供了依据
Objective To investigate the content of blood nitric oxide (NO) and its relationship with arterial oxygen pressure (PaO2) and carbon dioxide partial pressure (PaCO2) in patients with acute moderate and severe carbon monoxide poisoning. Methods Nitric acid reductase method was used to detect the blood levels of NO in 14 patients with acute CO moderate poisoning and 21 patients with severe poisoning. The correlations were analyzed with PaO2 and PaCO2. Results The blood levels of NO in patients with moderate and severe CO poisoning were (36.6 ± 9.9) and (35.7 ± 10.7) μmol / L, respectively, which were significantly lower than those in the control group [(6.4 ± 14.9) 3) μmol / L], the difference was significant (P <0.01). There was no significant difference between moderate and severe poisoning groups (P> 0.05). The linear correlation analysis showed that the blood levels of NO in patients with moderate and severe CO poisoning were positively correlated with PaO2, r values were 0.92 8,0. 891, all P <0 01; and PaCO2 no significant correlation . Conclusions Hypoxia in patients with moderate and severe CO poisoning may be an important reason for the decrease of blood NO level, which provides a basis for the inhalation of low concentration of NO for the treatment of acute CO poisoning