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以减毒疫苗株为基础的促进异源病毒蛋白表达的病毒疫苗载体 ,可诱生抗病毒载体和抗外源蛋白的免疫应答 ,这种策略尤其适用于 1型人类免疫缺陷症病毒 ( HIV- 1)这样的病毒。作者报告了以委内瑞拉马脑炎( VEE)病毒弱毒株为载体表达 HIV- 1蛋白的情况。 作者将 VEE病毒株改造成
Viral vaccine vectors that promote expression of heterologous viral proteins based on attenuated vaccine strains can induce an immune response against both antiviral and anti-foreign proteins, and this strategy is particularly applicable to HIV- 1) Such a virus. The authors report the case of expressing HIV-1 protein using the attenuated strain of equine encephalitis (VEE) virus in Venezuela as a vector. The author transformed the VEE virus strain into