目的探讨血清蛋白电泳检测对类风湿性关节炎(rheumatid arthritis,RA)患者的临床意义。方法测定38例类风湿关节炎患者和30例健康成人的血清蛋白电泳、血清蛋白含量及免疫球蛋白IgG、IgA、IgM和HSCRP的含量。结果RA患者血清蛋白电泳结果与对照组比α1、α2、γ球蛋白比例增高,白蛋白减低,差异有统计学意义(P<0.01)。结论类风湿关节炎患者血清蛋白电泳检测对临床有一定的参考价值。 Objective To investigate the clinical significance of serum protein electrophoresis in patients with rheumatoid arthritis (RA). Methods Serum protein electrophoresis, serum protein levels and immunoglobulin IgG, IgA, IgM and HSCRP levels were measured in 38 rheumatoid arthritis patients and 30 healthy adults. Results Compared with the control group, the serum protein electrophoresis results of RA patients showed an increased proportion of α1, α2 and γ globulin and decreased albumin, with significant difference (P <0.01). Conclusion Serum protein electrophoresis in patients with rheumatoid arthritis has certain clinical value.