[目的]观察分析脂蛋白(a)[LP(a)]水平与糖尿病肾病的相关性。[方法]使用日立7170全自动生化分析仪,采用免疫比浊法测定糖尿病无肾病患者、糖尿病肾病患者血清LP(a)水平并与正常对照者血清LP(a)水平进行比较。[结果]与正常对照组比较,糖尿病无肾病组血清LP(a)水平稍偏高,但差异无统计学意义(P﹥0.05),而糖尿病肾病组LP(a)水平显著升高,差异有统计学意义(P﹤0.01)。[结论]糖尿病肾病患者血清中LP(a)水平增高,可能与其致肾损伤机理有关。 [Objective] To observe and analyze the correlation between the level of lipoprotein (a) [LP (a)] and diabetic nephropathy. [Methods] Hitachi 7170 automatic biochemical analyzer was used to measure the level of LP (a) in patients with diabetic nephropathy and diabetic nephropathy by immunoturbidimetry and compared with the level of serum LP (a) in normal controls. [Results] Compared with the normal control group, the level of LP (a) in diabetic nephropathy group was slightly higher but the difference was not statistically significant (P> 0.05), while the level of LP (a) in diabetic nephropathy group was significantly increased Statistical significance (P <0.01). [Conclusion] The serum LP (a) level in patients with diabetic nephropathy increases, which may be related to the mechanism of renal injury.