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膜性肾病(MGN)是一种免疫介导的肾小球疾病,由抗体与未知抗原结合生成免疫复合物,随后激活补体,此过程可导致肾小球肿瘤坏死因子(TNF-α)生成增多,表现为尿TNF-α排泄量改变。已经证实尿TNF-α排泄量与MGN病人蛋白尿有关。研究表明己酮可可碱(Pentoxi-fylline)可抑制或减少TNF-α的合成。作者进行前瞻性试验评估己酮可可碱1.2g/d对原发性MGN病人蛋白尿的效应。
Membranous nephropathy (MGN) is an immune-mediated glomerular disease by which an antibody binds to an unknown antigen to form an immune complex and subsequently activates complement, a process that results in an increased production of glomerular tumor necrosis factor (TNF-α) , Manifested as changes in urinary TNF-α excretion. Urinary TNF-a excretion has been shown to be associated with proteinuria in MGN patients. Studies have shown that Pentoxi-fylline can inhibit or reduce the synthesis of TNF-α. The authors conducted prospective trials to evaluate the effect of pentoxifylline at 1.2 g / day on proteinuria in patients with primary MGN.