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为研究粘附分子在溃疡性结肠炎(UC)发病机制中的作用,应用流式细胞术测定34例 UC 患者活检组织及血液中粘附分子 CD_(44)及细胞间粘附分子 CD_(54),并与20例正常人对照。结果显示,UC 患者组织和血液中 CD_(44)、CD_(54)较正常人明显升高(P<0.01),缓解期 UC 患者上述指标较活动期显著下降(P<0.05),但仍明显高于正常人(P<0.05)。本文结果提示粘附分子水平增加在 UC 的发病机制中起重要作用,对判断或监测 UC 患者病情进展及活动转归具有一定意义。
To study the role of adhesion molecules in the pathogenesis of ulcerative colitis (UC), the expression of adhesion molecule CD_ (44) and intercellular adhesion molecule CD_ (54) in biopsies and blood of 34 patients with UC were determined by flow cytometry ), And with 20 normal controls. The results showed that the levels of CD_ (44) and CD_ (54) in UC patients were significantly higher than those in normal controls (P <0.01), while those in UC patients were significantly lower than those in active stage (P <0.05) Higher than normal (P <0.05). Our results suggest that increased adhesion molecules play an important role in the pathogenesis of UC and have some significance in judging or monitoring the progression of disease and the outcome of UC.