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目的:统计不良孕产史患者中异常核型的比例,探讨不良孕产史与细胞遗传学的关系。方法:对1 365例具有不良孕产史的患者采用外周血进行淋巴细胞培养,制备染色体标本,G显带核型分析后结合临床资料对其进行染色体异常与男女发生的比例及不良孕产次数与染色体异常的关系进行统计学分析。结果:1 365例完成核型分析的检查者中,染色体异常20例,异常检出率1.47%。主要以男性染色体异常为主,男女性别与染色体异常检出率的差异无统计学意义,不良孕产史次数与染色体异常检出率差异有统计学意义。结论:染色体异常是导致不良孕产史等疾病的重要原因之一,进行染色体检查,可为临床诊断和治疗提供科学依据。
OBJECTIVE: To analyze the proportion of abnormal karyotypes in patients with unhealthy pregnancy history and to explore the relationship between poor pregnancy history and cytogenetics. Methods: A total of 1 365 cases of patients with poor pregnancy history were cultured with lymphocytes in peripheral blood to prepare chromosomal specimens. The ratio of chromosomal abnormalities to men and women and the number of unfavorable pregnancy were determined by combining clinical data with G-banding karyotype analysis And chromosomal abnormalities were statistically analyzed. Results: Among the 365 patients who completed the karyotype analysis, 20 cases were chromosomal abnormalities with an abnormality rate of 1.47%. The main male chromosomal abnormalities, male and female gender and chromosomal abnormalities were no significant difference in the detection rate, the number of adverse pregnancy history and chromosomal abnormalities were statistically significant difference. Conclusion: Chromosomal abnormalities are one of the important causes of diseases such as poor pregnancy history. Chromosome examination may provide a scientific basis for clinical diagnosis and treatment.