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目的 :观察中药补肾煎对绝经后动脉粥样硬化模型家兔血脂、血清一氧化氮 (NO)、血浆内皮素 (ET)以及主动脉血管组织形态、细胞超微结构等的影响。方法 :去势术 +静注牛血清白蛋白 +0 .5 %高脂饮食造成绝经后动脉粥样硬化动物模型。并灌服中药 12周后检测相关指标。结果 :补肾煎能明显抑制血清胆固醇、甘油三脂异常升高 (P <0 .0 1) ,提高NO水平 (P <0 .0 5 ) ,降低ET含量 (P <0 .0 5 ) ,并对细胞超微结构有保护作用。结论 :补肾煎具有防止血脂升高、维持ET/NO平衡、抗氧化 ,保护内皮细胞功能的作用
Objective: To observe the effects of Bushen Jian with traditional Chinese medicine on blood lipid, serum nitric oxide (NO), plasma endothelin (ET), aortic vascular morphology and ultrastructure of rabbits in postmenopausal atherosclerosis model. METHODS: The animal model of postmenopausal atherosclerosis was induced by castration + intravenous injection of bovine serum albumin + 0.5% high fat diet. And after taking Chinese medicine for 12 weeks, test relevant indicators. Results: Kidney-tonifying decoction can obviously inhibit the abnormal increase of serum cholesterol and triglyceride (P <0.01), increase the level of NO (P <0.05), and decrease the content of ET (P <0.05). It has a protective effect on the ultrastructure of cells. Conclusion : Kidney-tonifying decoction can prevent the increase of blood lipids, maintain the balance of ET/NO, antioxidation, and protect the function of endothelial cells.