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本文观察了失血性休克条件下大鼠白细胞介素1（IL-1）与内毒素的关系。结果表明：失血性休克早期血浆IL－1及ET均明显升高，前者升高在先；无菌大鼠失血性休克后IL－1活性也升高，但ET无明显变化；预先给大鼠口服乳果糖以清洁肠道，或静注内毒素抗体，休克后血浆IL－1活性仍然明显升高，而血浆ET无明显升高；大鼠失血后1h将失血回输，再灌注后5d血浆IL－1与ET呈平行性变化，乳果糖或抗内毒素抗体治疗后，血浆IL－1活性及ET水平均明显降低。上述结果提示，失血性休克早期血浆IL－1活性升高与内毒素刺激无关，但后期IL－1活性升高与内毒素相关，内毒素主要来源于肠道。
This article investigates the relationship between interleukin-1 (IL-1) and endotoxin in rats under hemorrhagic shock. The results showed that in the early stage of hemorrhagic shock, the plasma levels of IL-1 and ET were significantly increased, the former increased first; the activity of IL-1 in aseptic rats was also increased after hemorrhagic shock, but ET did not change significantly; Oral lactulose to clean the intestine, or intravenous injection of endotoxin antibody, plasma IL-1 activity remained significantly increased after shock, but no significant increase in plasma ET; 1 h after blood loss in rats will lose blood transfusion, 5 d after reperfusion plasma IL-1 and ET were parallel changes, lactulose or anti-endotoxin antibody treatment, plasma IL-1 activity and ET levels were significantly lower. The above results suggest that elevated plasma IL-1 activity in early stage of hemorrhagic shock has nothing to do with endotoxin stimulation, but increased late IL-1 activity is associated with endotoxin, mainly from the intestine.