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本文研究了15-甲基-PGF_(2α)中断中期妊娠的作用机制。8例中期妊娠病人用含有3.0mg 15-甲基-PGF_(2α)长效阴道栓剂中断妊娠,于治疗前,治疗期间不同间隔时间以及流产后的5～15分钟分别收集血液,有2例流产后的2及5小时也采取血样,分离血浆冷冻保存备用。用带有多离子探测的气象色谱-质谱仪测定PGF_(2α)和PGE_2的主要代谢产物即15-酮-二氢-PGF_(2α)和15-酮-二氢-PGE_2。每4个病人一系列
This article studies the role of 15-methyl-PGF_ (2α) in interrupting gestational pregnancy. Eight pregnant women in the second trimester of pregnancy discontinued pregnancy with a long-acting suppository containing 3.0 mg of 15-methyl-PGF 2α, and blood was collected before treatment, at various intervals during treatment, and 5-15 minutes after abortion, with 2 abortions After 2 and 5 hours also take a blood sample, isolated plasma frozen reserve. The main metabolites of PGF_ (2α) and PGE_2, namely 15-keto-PGF_ (2α) and 15-keto-dihydro-PGE_2, were determined by gas chromatography-mass spectrometry with multi-ion detection. A series of 4 patients