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15－甲基PGF2α甲酯（PG05）对小鼠有明显的抗早孕作用。（＋）PGOS为有活性的立体异构体，其抗早孕和致腹泻作用均比（±）PGOS强，治疗指数与（±）PG05基本一致。大鼠于妊娠第7、8、9天，皮下注射（±）PG050.5mg／kg有明显的抗早孕作用；同样剂量的PGOS对去卵巢后，靠外源性孕酮和雌酮维持妊娠的大鼠无抗早孕作用。PGOS20μg／ml既可抑制hCG刺激黄体细胞分泌cAMP，又能桔抗SBr－cAMP刺激黄体细胞分泌孕酮，PG05可能在2个或2个以上环节上抑制大鼠卵巢黄体功能。
Methyl PGF2α methyl ester (PG05) has obvious anti-pregnancy effect on mice. (+) PGOS is an active stereoisomer, and its anti-pregnancy and diarrhea effects are stronger than (±) PGOS, and the therapeutic index is basically the same as (±) PG05. Rats on the 7th, 8th and 9th day of gestation had a significant anti-pregnancy effect with subcutaneous injection of (PG050.5mg / kg); the same dose of PGOS maintained the pregnancy by exogenous progesterone and estrone after ovariectomized No anti-pregnancy effect of rats. PGOS20μg / ml can inhibit the hCG-stimulated cAMP secretion of luteal cells, but also orange anti-SBr-cAMP stimulated progesterone secretion of luteal cells, PG05 may be two or more aspects of the inhibition of ovarian luteal function in rats.