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目的：研究细胞周期素 Ｄ１ （ｃｙｃｌｉｎ Ｄ１）表达对肾母细胞瘤的影响。方法：应用原位杂交技术检测 ２３例肾母细胞瘤 ｃｙｃｌｉｎ Ｄ１ 表达情况。结果：１５ 例检测到ｃｙｃｌｉｎ Ｄ１ 表达阳性细胞，表达指数 ５６％ ～４３９％ 。ｃｙｃｌｉｎ Ｄ１ 表达阳性组瘤体重量显著大于阴性组（ Ｐ＜ ００５）；ｃｙｃｌｉｎ Ｄ１ 高表达者瘤体重量明显大于低表达者（ Ｐ＜ ００５）。临床晚期标本ｃｙｃｌｉｎ Ｄ１ 表达指数明显高于早期标本（ Ｐ＜ ００５）；不同组织类型标本 ｃｙｃｌｉｎ Ｄ１ 表达指数无显著性差异（ Ｐ＞ ００５）。ｃｙｃｌｉｎ Ｄ１ 表达指数与瘤体重量呈正相关（ｒ＝ ０５３， Ｐ＜ ００５）。结论：ｃｙｃｌｉｎ Ｄ１表达与肾母细胞瘤发生发展关系密切；过度表达时，肾母细胞瘤细胞增殖周期演进快，肿瘤生长迅速，预后不良。
Objective: To investigate the effect of cyclin D1 expression on nephroblastoma. Methods: The in situ hybridization was used to detect the expression of cyclin D1 in 23 cases of nephroblastoma. Results: The positive expression of cyclin D1 was detected in 15 cases with expression index of 56% ~ 439%. The tumor weight of cy-clin D1-positive group was significantly higher than that of the negative group (P <005). The tumor weight of cyclin D1 was significantly higher than that of the low expression group (P <005). The cyclin D1 expression index in clinical specimens was significantly higher than that in early specimens (P <005). There was no significant difference in cyclin D1 expression between different tissues (P> 0.05). The expression of cyclin D1 was positively correlated with tumor weight (r = 053, P <005). Conclusion: The expression of cyclin D1 is closely related to the occurrence and development of nephroblastoma. When overexpressed, the cell cycle of nephroblastoma progresses rapidly and the tumor grows rapidly with poor prognosis.