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目的 探讨胃癌组织中细胞周期素D1(cyclinD1)的表达及其意义。方法 采用S P免疫组织化学方法测定各种胃癌、不典型增生、正常胃粘膜组织中cyclinD1的表达状况。结果 胃的不同病变组织中cyclinD1的表达率分别为 :进展期胃癌6 2 .5 0 % (2 5 / 4 0 ) ,早期胃癌 6 0 .0 0 % (12 / 2 0 ) ,淋巴结转移胃癌 5 5 .0 0 % (11/ 2 0 ) ,Ⅱ～Ⅲ级不典型增生 45 .0 0 % (9/ 2 0 ) ,正常胃粘膜15 .0 0 % (3/ 2 0 )。胃癌和胃粘膜不典型增生组织的cyclinD1表达率均显著高于正常胃粘膜组织 (P <0 .0 1) ;早期胃癌、进展期胃癌以及淋巴结转移的胃癌组织间cyclinD1的表达无显著性差异 (P >0 .0 5 )。结论 cyclinD1的过度表达与胃粘膜上皮组织的增生和胃癌的发生关系密切 ,而与胃癌的进展和淋巴结转移无关。
Objective To investigate the expression of cyclin D1 in gastric carcinoma and its significance. Methods The expression of cyclinD1 in gastric cancer, atypical hyperplasia and normal gastric mucosa was detected by SP immunohistochemistry. Results The expression rates of cyclinD1 in different gastric tissues were 62.5% (25/40) in advanced gastric cancer, 60.0% (12/20) in early gastric cancer and 5 5. 0 0% (11/20), Ⅱ ~ Ⅲ grade atypical hyperplasia 45 .0 0% (9/20), normal gastric mucosa 15 .0 0% (3/20). The expression of cyclinD1 in gastric cancer and gastric atypical hyperplasia tissues was significantly higher than that in normal gastric mucosa (P <0.01). There was no significant difference in the expression of cyclinD1 between early gastric cancer, advanced gastric cancer and gastric cancer with lymph node metastasis P> 0 .0 5). Conclusion The overexpression of cyclinD1 is closely related to the proliferation of gastric epithelial tissue and the occurrence of gastric cancer, but not to the progress of gastric cancer and lymph node metastasis.