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为了解非腆岛素依赖型糖尿病(NIDDM)患者的肾功能,为临床治疗和预后判断提供依据,对137例 NIDDM 患者和44例正常对照者(NC)进行~(99m)Tc-DTPA 肾动态显像,同时获肾小球滤过率(GFR)和肾功能曲线;其中126例 NIDDM患者和另17例 NC 行~(99m)Tc-双半胱氨酸(EC)肾小管分泌功能测定。结果:不同病期各组 NIDDM 患者的 GFR 均显著低于NC(t=7.17～13.73,P<0.01)。2种显像剂用于测定肾小管分泌功能,不同病期组 NIDDM 心者的峰时均较 NC 明显后延(t=3.15～8.25,P<0.01);不同病期10和20分钟残存率均升高,与 NC 比较,以~(99m)Tc-EC 测定结果更为明显(t=2.11～2.18,P<0.05和 t=2.76～7.21,P<0.01)。因此,NIDDM 患者的肾脏滤过和分泌功能均受损,其程度随病期的延长而加重。
To investigate the renal function in patients with non-insulin dependent diabetes mellitus (NIDDM) and to provide basis for clinical treatment and prognosis, 137 patients with NIDDM and 44 normal controls (NC) underwent 99m Tc-DTPA renal dynamic (GFR) and renal function curves of 126 patients with NIDDM and 17 patients with NC (99m) Tc-bis-cysteine (EC) renal tubular secretion were measured. Results: The GFR of NIDDM patients in different stages was significantly lower than that of NC (t = 7.17-13.73, P <0.01). Two kinds of imaging agents were used to determine the renal tubular secretion. The peak time of NIDDM in different stages was significantly delayed than that in NC (t = 3.15-8.25, P <0.01). The residual rates at 10 and 20 minutes (99m) Tc-EC was significantly higher than that of NC (t = 2.11-2.18, P <0.05 and t = 2.76-7.21, P <0.01). Therefore, NIDDM patients with renal filtration and secretory function are impaired, the extent increased with the extension of the disease.