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[目的]探讨胃癌患者血清VEGF及MMP-2的表达与胃癌浸润和转移的关系。[方法]应用ELISA法检测69例胃癌患者血清VEGF、MMP-2的表达水平,并分析其与临床病理因素间的关系。[结果]低分化胃癌患者血清VEGF阳性率(64.0%)显著高于高、中分化者(36.8%,P<0.05);且VEGF、MMP-2表达与肿瘤的浸润深度、淋巴结转移、远处转移及TNM分期均密切相关(P<0.05)。胃癌患者血清VEGF的阳性表达与MMP-2的阳性表达呈正相关(rs=0.322,P<0.01)。[结论]VEGF和MMP-2在胃癌的浸润和转移中起重要作用,血清VEGF、MMP-2的表达水平可作为了解胃癌生物学行为和判断预后的指标。
[Objective] To investigate the relationship between the expression of VEGF and MMP-2 and the infiltration and metastasis of gastric cancer in patients with gastric cancer. [Method] The serum levels of VEGF and MMP-2 in 69 cases of gastric cancer were detected by ELISA, and their relationship with clinicopathological factors were analyzed. [Results] The positive rate of VEGF in patients with poorly differentiated gastric cancer (64.0%) was significantly higher than that in patients with high or moderate differentiation (36.8%, P <0.05). The expressions of VEGF and MMP-2 were correlated with the depth of tumor invasion, lymph node metastasis Metastasis and TNM staging were closely related (P <0.05). The positive expression of VEGF in gastric cancer patients was positively correlated with the positive expression of MMP-2 (rs = 0.322, P <0.01). [Conclusion] VEGF and MMP-2 play an important role in the invasion and metastasis of gastric cancer. The expression levels of VEGF and MMP-2 can be used as indicators for understanding the biological behavior of gastric cancer and prognosis.