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安体舒通是一种具有强抗雄激素活性的醛固酮拮抗剂,能促进睾酮(T)在外周转换为雌二醇(E_2);并通过抑制17-羟化酶和17,20裂解酶活性而抑制T合成,从而使血清T浓度降低;此外还能抑制5α-还原酶活性;是雄激素受体拮抗剂。为此常用于治疗妇女多毛症。但文献推荐的剂量及产生的副作用很不一致,有报导日剂量100～200 mg共3～12个月无副反应;但亦有报导日剂量50或200mg者月经不规则发生率各为14%及27%。为研究本药副作用发生率及类型,本文收集16例患特发性多毛症的绝经前妇女(年龄19～42岁),在月经
Spironolactone is an aldosterone antagonist with potent anti-androgenic activity that promotes the conversion of testosterone (T) to estradiol (E2) in the periphery; and by inhibiting 17-hydroxylase and 17,20-lyase activity While inhibiting the synthesis of T, so that serum T concentration decreased; in addition to inhibit 5α-reductase activity; androgen receptor antagonist. This is commonly used for the treatment of women with hirsutism. However, the literature recommended dose and side effects are very inconsistent, there are reports of 100-200 mg daily dose of 3 to 12 months without side effects; but there are also reports of daily doses of 50 or 200mg were menstrual irregularities were 14% and 27%. To study the incidence and type of side effects of this drug, 16 premenopausal women (aged 19-42 years) with idiopathic hirsutism were collected in this study.