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目的：观察在增生性玻璃体视网膜病变（PVR）模型中几种早期炎性细胞因子的含量变化及其与PVR形成时相的关系、方法：采集巨噬细胞诱发的兔眼PVR模型的玻璃体液用双抗体夹心法酶联免疫吸附测试（ELISA）试剂盒，检测样本中肿瘤坏死因子一α（TNF-α），白细胞介素一8（IL-8）和白细胞介素一6（IL-6）的含量，并进行多元回归拟合曲线分析．结果：TNF-α在巨噬细胞注入后7d上升，21d达高峰值，为309ng／L;IL-8与IL-6在7d～21d也维持高水平，在14d分别达高峰值1325ng／L和998ng／L与对照组比较差异均有非常显著性.结论：3种早期炎性细胞因子TNF-α，IL-8和IL-6在本模型的炎症期和细胞增生期均呈明显的高水平，在癌痕期水平降低，提示它们对眼内细胞增生具有重要的启动和调控作用．
OBJECTIVE: To observe the changes of several early inflammatory cytokines in PVR model and its relationship with the PVR formation phase. Methods: The vitreous fluid of PVR model induced by macrophages Tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and interleukin-6 (IL-6) were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) The content, and multiple regression fitting curve analysis. Results: The level of TNF-α increased on the 7th day after injection of macrophages, reaching the peak value of 309ng / L on the 21st day. IL-8 and IL-6 also maintained high levels on the 7th to 21st day and peaked at 1325ng / L on the 14th day respectively 998ng / L compared with the control group were significantly different.Conclusion: The three kinds of early inflammatory cytokines TNF-α, IL-8 and IL-6 in the model of inflammation and cell hyperplasia were significantly higher , Lower levels of cancer marks, suggesting that they have an important role in the initiation and regulation of intraocular cell proliferation.