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应用卵蛋白致敏和刺激小鼠复制过敏性哮喘模型观察血栓素Ａ２合成酶选择性抑制剂ＯＫＹ－０４６对抗原引起呼吸道嗜酸性粒细胞（ＥＯＳ）浸润的影响。结果表明正常对照小鼠支气管肺泡灌洗液（ＢＡＬＦ）中未见到ＥＯＳ；致敏小鼠给予抗原反复刺激后，ＢＡＬＦ中ＥＯＳ急剧增多。ＯＫＹ－０４６的不同剂量分别导致ＢＡＬＦ中ＥＯＳ数下降３６．９％，５８．０％及６８．９％。还发现ＯＫＹ－０４６抑制ＥＯＳ对气道的侵润伴随着ＩＬ－５和ＩＬ－２水平的明显降低，这些结果提示ＯＫＹ－０４６通过抑制ＣＤ４Ｔ淋巴细胞分泌细胞因子从而抑制了ＥＯＳ在气道的积聚。
The effect of OKY-046, a selective inhibitor of thromboxane A2 synthase, on the eosinophilic respiratory tract eosinophil (EOS) infiltration was observed using the ovalbumin-sensitized and stimulated mouse model of allergic asthma. The results showed that EOS was not found in BALF in normal control mice. EOS in BALF increased sharply after sensitized mice repeatedly received antigens. Different doses of OKY-046 resulted in a decrease of 36.9%, 58.0% and 68.9% in BALF. It was also found that OKY-046 inhibited EOS infiltration in the airway accompanied by a significant decrease of IL-5 and IL-2 levels. These results suggest that OKY-046 inhibits the accumulation of EOS in the airway by inhibiting the secretion of cytokines by CD4 T lymphocytes .